Comparison of the oxidation of carcinogenic aristolochic acid I and II by microsomal cytochromes P450 in vitro: experimental and theoretical approaches

ABSTRACT: The herbal drug aristolochic acid, a natural mixture of 8-methoxy-6-nitrophenanthro[3,4-d]-1,3-dioxole-5-carboxylic acid (AAI) and 6-nitrophenanthro[3,4-d]-1,3-dioxole-5-carboxylic acid (AAII), is derived from Aristolochia species and is the cause of two nephropathies. Ingestion of aristol...

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Publicado en:Monatsh Chem
Autores principales: Martínek, Václav, Bárta, František, Hodek, Petr, Frei, Eva, Schmeiser, Heinz H., Arlt, Volker M., Stiborová, Marie
Formato: Artigo
Lenguaje:Inglês
Publicado: Springer Vienna 2017
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Original Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5653735/
https://ncbi.nlm.nih.gov/pubmed/29104318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00706-017-2014-9
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