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Lipid-Sorting Specificity Encoded in K-Ras Membrane Anchor Regulates Signal Output
K-Ras is targeted to the plasma membrane by a C-terminal membrane anchor that comprises a farnesyl-cysteine-methyl-ester and a polybasic domain. We used quantitative spatial imaging and atomistic molecular dynamics simulations to examine molecular details of K-Ras plasma membrane binding. We found t...
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| Veröffentlicht in: | Cell |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5653213/ https://ncbi.nlm.nih.gov/pubmed/28041850 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.11.059 |
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