Overcoming imatinib resistance conferred by the BIM deletion polymorphism in chronic myeloid leukemia with splice-switching antisense oligonucleotides

Many tyrosine kinase-driven cancers, including chronic myeloid leukemia (CML), are characterized by high response rates to specific tyrosine kinase inhibitors (TKIs) like imatinib. In East Asians, primary imatinib resistance is caused by a deletion polymorphism in Intron 2 of the BIM gene, whose pro...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Oncotarget
Κύριοι συγγραφείς: Liu, Jun, Bhadra, Malini, Sinnakannu, Joanna Rajeswary, Yue, Wan Lin, Tan, Cheryl Weiqi, Rigo, Frank, Ong, S.Tiong, Roca, Xavier
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Impact Journals LLC 2017
Θέματα:
Research Paper
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5652800/
https://ncbi.nlm.nih.gov/pubmed/29100409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.20658
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