A novel Fc-engineered human ICAM-1/CD54 antibody with potent anti-myeloma activity developed by cellular panning of phage display libraries

To identify antibodies suitable for multiple myeloma (MM) immunotherapy, a cellular screening approach was developed using plasma cell lines JK-6L and INA-6 and human synthetic single-chain fragment variable (scFv) phage libraries. Isolated phage antibodies were screened for myeloma cell surface rea...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Klausz, Katja, Cieker, Michael, Kellner, Christian, Oberg, Hans-Heinrich, Kabelitz, Dieter, Valerius, Thomas, Burger, Renate, Gramatzki, Martin, Peipp, Matthias
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5652799/
https://ncbi.nlm.nih.gov/pubmed/29100408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.20641
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