The pVHL(172) isoform is not a tumor suppressor and up-regulates a subset of pro-tumorigenic genes including TGFB1 and MMP13

The von Hippel-Lindau (VHL) tumor suppressor gene is often deleted or mutated in ccRCC (clear cell renal cell carcinoma) producing a non-functional protein. The gene encodes two mRNA, and three protein isoforms (pVHL(213), pVHL(160) and pVHL(172)). The pVHL protein is part of an E3 ligase complex in...

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Publicado en:Oncotarget
Autores principales: Hascoet, Pauline, Chesnel, Franck, Jouan, Florence, Goff, Cathy Le, Couturier, Anne, Darrigrand, Eric, Mahe, Fabrice, Rioux-Leclercq, Nathalie, Goff, Xavier Le, Arlot-Bonnemains, Yannick
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5652680/
https://ncbi.nlm.nih.gov/pubmed/29100286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.18376
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