The pVHL(172) isoform is not a tumor suppressor and up-regulates a subset of pro-tumorigenic genes including TGFB1 and MMP13

The von Hippel-Lindau (VHL) tumor suppressor gene is often deleted or mutated in ccRCC (clear cell renal cell carcinoma) producing a non-functional protein. The gene encodes two mRNA, and three protein isoforms (pVHL(213), pVHL(160) and pVHL(172)). The pVHL protein is part of an E3 ligase complex in...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Oncotarget
Autors principals: Hascoet, Pauline, Chesnel, Franck, Jouan, Florence, Goff, Cathy Le, Couturier, Anne, Darrigrand, Eric, Mahe, Fabrice, Rioux-Leclercq, Nathalie, Goff, Xavier Le, Arlot-Bonnemains, Yannick
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2017
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5652680/
https://ncbi.nlm.nih.gov/pubmed/29100286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.18376
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars