Inhibition of 12/15-Lipoxygenase Protects Against β-Cell Oxidative Stress and Glycemic Deterioration in Mouse Models of Type 1 Diabetes

Islet β-cell dysfunction and aggressive macrophage activity are early features in the pathogenesis of type 1 diabetes (T1D). 12/15-Lipoxygenase (12/15-LOX) is induced in β-cells and macrophages during T1D and produces proinflammatory lipids and lipid peroxides that exacerbate β-cell dysfunction and...

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Détails bibliographiques
Publié dans:Diabetes
Auteurs principaux: Hernandez-Perez, Marimar, Chopra, Gaurav, Fine, Jonathan, Conteh, Abass M., Anderson, Ryan M., Linnemann, Amelia K., Benjamin, Chanelle, Nelson, Jennifer B., Benninger, Kara S., Nadler, Jerry L., Maloney, David J., Tersey, Sarah A., Mirmira, Raghavendra G.
Format: Artigo
Langue:Inglês
Publié: American Diabetes Association 2017
Sujets:
Pharmacology and Therapeutics
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5652601/
https://ncbi.nlm.nih.gov/pubmed/28842399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db17-0215
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