Hydrogen Peroxide Activated Quinone Methide Precursors with Enhanced DNA Cross-Linking Capability and Cytotoxicity towards Cancer Cells

Quinone methide (QM) formation induced by endogenously generated H(2)O(2) is attractive for biological and biomedical applications. To overcome current limitations due to low biological activity of H(2)O(2)-activated QM precursors, we are introducing herein several new arylboronates with electron do...

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Veröffentlicht in:Eur J Med Chem
Hauptverfasser: Wang, Yibin, Fan, Heli, Balakrishnan, Kumudha, Lin, Zechao, Cao, Sheng, Chen, Wenbing, Fan, Yukai, Guthrie, Quibria A., Sun, Huabing, Teske, Kelly A., Gandhi, Varsha, Arnold, Leggy A., Peng, Xiaohua
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5652303/
https://ncbi.nlm.nih.gov/pubmed/28388522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2017.03.041
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