Hydrogen Peroxide Activated Quinone Methide Precursors with Enhanced DNA Cross-Linking Capability and Cytotoxicity towards Cancer Cells

Quinone methide (QM) formation induced by endogenously generated H(2)O(2) is attractive for biological and biomedical applications. To overcome current limitations due to low biological activity of H(2)O(2)-activated QM precursors, we are introducing herein several new arylboronates with electron do...

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Detalhes bibliográficos
Publicado no:Eur J Med Chem
Main Authors: Wang, Yibin, Fan, Heli, Balakrishnan, Kumudha, Lin, Zechao, Cao, Sheng, Chen, Wenbing, Fan, Yukai, Guthrie, Quibria A., Sun, Huabing, Teske, Kelly A., Gandhi, Varsha, Arnold, Leggy A., Peng, Xiaohua
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5652303/
https://ncbi.nlm.nih.gov/pubmed/28388522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2017.03.041
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