IRX3 Promotes the Browning of White Adipocytes and Its Rare Variants are Associated with Human Obesity Risk

BACKGROUND: IRX3 was recently reported as the effector of the FTO variants. We aimed to test IRX3's roles in the browning program and to evaluate the association between the genetic variants in IRX3 and human obesity. METHODS: IRX3 expression was examined in beige adipocytes in human and mouse...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Zou, Yaoyu, Lu, Peng, Shi, Juan, Liu, Wen, Yang, Minglan, Zhao, Shaoqian, Chen, Na, Chen, Maopei, Sun, Yingkai, Gao, Aibo, Chen, Qingbo, Zhang, Zhiguo, Ma, Qinyun, Ning, Tinglu, Ying, Xiayang, Jin, Jiabin, Deng, Xiaxing, Shen, Baiyong, Zhang, Yifei, Yuan, Bo, Kauderer, Sophie, Liu, Simin, Hong, Jie, Liu, Ruixin, Ning, Guang, Wang, Weiqing, Gu, Weiqiong, Wang, Jiqiu
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5652024/
https://ncbi.nlm.nih.gov/pubmed/28988979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2017.09.010
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