Blocking FSH Induces Thermogenic Adipose Tissue and Reduces Body Fat

Menopause is associated with bone loss and enhanced visceral adiposity. We have shown previously that a polyclonal antibody (Ab) to the β-subunit of the pituitary hormone Fsh increases bone mass in mice. Here, we report that this Ab sharply reduces adipose tissue in wild type mice, phenocopying gene...

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Publicat a:Nature
Autors principals: Liu, Peng, Ji, Yaoting, Yuen, Tony, Rendina-Ruedy, Elizabeth, DeMambro, Victoria E., Dhawan, Samarth, Abu-Amer, Wahid, Izadmehr, Sudeh, Zhou, Bin, Shin, Andrew, Latif, Rauf, Thangeswaran, Priyanthan, Gupta, Animesh, Li, Jianhua, Shnayder, Valeria, Robinson, Samuel T., Yu, Yue Eric, Zhang, Xingjian, Yang, Feiran, Lu, Ping, Zhou, Yu, Zhu, Ling-Ling, Oberlin, Douglas J., Davies, Terry F., Reagan, Michaela R., Brown, Aaron, Kumar, T. Rajendra, Epstein, Solomon, Iqbal, Jameel, New, Maria I., Molina, Henrik, van Klinken, Jan B., Guo, Edward X., Buettner, Christoph, Haider, Shozeb, Bian, Zhuan, Sun, Li, Rosen, Clifford J., Zaidi, Mone
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5651981/
https://ncbi.nlm.nih.gov/pubmed/28538730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature22342
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