Blocking FSH Induces Thermogenic Adipose Tissue and Reduces Body Fat

Menopause is associated with bone loss and enhanced visceral adiposity. We have shown previously that a polyclonal antibody (Ab) to the β-subunit of the pituitary hormone Fsh increases bone mass in mice. Here, we report that this Ab sharply reduces adipose tissue in wild type mice, phenocopying gene...

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Publicado no:Nature
Main Authors: Liu, Peng, Ji, Yaoting, Yuen, Tony, Rendina-Ruedy, Elizabeth, DeMambro, Victoria E., Dhawan, Samarth, Abu-Amer, Wahid, Izadmehr, Sudeh, Zhou, Bin, Shin, Andrew, Latif, Rauf, Thangeswaran, Priyanthan, Gupta, Animesh, Li, Jianhua, Shnayder, Valeria, Robinson, Samuel T., Yu, Yue Eric, Zhang, Xingjian, Yang, Feiran, Lu, Ping, Zhou, Yu, Zhu, Ling-Ling, Oberlin, Douglas J., Davies, Terry F., Reagan, Michaela R., Brown, Aaron, Kumar, T. Rajendra, Epstein, Solomon, Iqbal, Jameel, New, Maria I., Molina, Henrik, van Klinken, Jan B., Guo, Edward X., Buettner, Christoph, Haider, Shozeb, Bian, Zhuan, Sun, Li, Rosen, Clifford J., Zaidi, Mone
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5651981/
https://ncbi.nlm.nih.gov/pubmed/28538730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature22342
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