Blocking FSH Induces Thermogenic Adipose Tissue and Reduces Body Fat

Menopause is associated with bone loss and enhanced visceral adiposity. We have shown previously that a polyclonal antibody (Ab) to the β-subunit of the pituitary hormone Fsh increases bone mass in mice. Here, we report that this Ab sharply reduces adipose tissue in wild type mice, phenocopying gene...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nature
Prif Awduron: Liu, Peng, Ji, Yaoting, Yuen, Tony, Rendina-Ruedy, Elizabeth, DeMambro, Victoria E., Dhawan, Samarth, Abu-Amer, Wahid, Izadmehr, Sudeh, Zhou, Bin, Shin, Andrew, Latif, Rauf, Thangeswaran, Priyanthan, Gupta, Animesh, Li, Jianhua, Shnayder, Valeria, Robinson, Samuel T., Yu, Yue Eric, Zhang, Xingjian, Yang, Feiran, Lu, Ping, Zhou, Yu, Zhu, Ling-Ling, Oberlin, Douglas J., Davies, Terry F., Reagan, Michaela R., Brown, Aaron, Kumar, T. Rajendra, Epstein, Solomon, Iqbal, Jameel, New, Maria I., Molina, Henrik, van Klinken, Jan B., Guo, Edward X., Buettner, Christoph, Haider, Shozeb, Bian, Zhuan, Sun, Li, Rosen, Clifford J., Zaidi, Mone
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2017
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5651981/
https://ncbi.nlm.nih.gov/pubmed/28538730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature22342
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