TNFR1 inhibition with a Nanobody protects against EAE development in mice

TNF has as detrimental role in multiple sclerosis (MS), however, anti-TNF medication is not working. Selective TNF/TNFR1 inhibition whilst sparing TNFR2 signaling reduces the pro-inflammatory effects of TNF but preserves the important neuroprotective signals via TNFR2. We previously reported the gen...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Steeland, Sophie, Van Ryckeghem, Sara, Van Imschoot, Griet, De Rycke, Riet, Toussaint, Wendy, Vanhoutte, Leen, Vanhove, Christian, De Vos, Filip, Vandenbroucke, Roosmarijn E., Libert, Claude
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5651799/
https://ncbi.nlm.nih.gov/pubmed/29057962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-13984-y
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