Decreased TNF Levels and Improved Retinal Ganglion Cell Survival in MMP-2 Null Mice Suggest a Role for MMP-2 as TNF Sheddase

Matrix metalloproteinases (MMPs) have been designated as both friend and foe in the central nervous system (CNS): while being involved in many neurodegenerative and neuroinflammatory diseases, their actions appear to be indispensable to a healthy CNS. Pathological conditions in the CNS are therefore...

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Bibliographische Detailangaben
Veröffentlicht in:Mediators Inflamm
Hauptverfasser: De Groef, Lies, Salinas-Navarro, Manuel, Van Imschoot, Griet, Libert, Claude, Vandenbroucke, Roosmarijn E., Moons, Lieve
Format: Artigo
Sprache:Inglês
Veröffentlicht: Hindawi Publishing Corporation 2015
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4586990/
https://ncbi.nlm.nih.gov/pubmed/26451076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2015/108617
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