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Chemical substitutions in the selectivity filter of potassium channels do not rule out constricted-like conformations for C-type inactivation
In many K(+) channels, prolonged activating stimuli lead to a time-dependent reduction in ion conduction, a phenomenon known as C-type inactivation. X-ray structures of the KcsA channel suggest that this inactivated state corresponds to a “constricted” conformation of the selectivity filter. However...
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| Vydáno v: | Proc Natl Acad Sci U S A |
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| Hlavní autoři: | , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
2017
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5651753/ https://ncbi.nlm.nih.gov/pubmed/28973956 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1706983114 |
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