Discovery of a Prefusion Respiratory Syncytial Virus F-Specific Monoclonal Antibody That Provides Greater In Vivo Protection than the Murine Precursor of Palivizumab

Palivizumab, a humanized murine monoclonal antibody that recognizes antigenic site II on both the prefusion (pre-F) and postfusion (post-F) conformations of the respiratory syncytial virus (RSV) F glycoprotein, is the only prophylactic agent approved for use for the treatment of RSV infection. Howev...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Zhao, Min, Zheng, Zi-Zheng, Chen, Man, Modjarrad, Kayvon, Zhang, Wei, Zhan, Lu-Ting, Cao, Jian-Li, Sun, Yong-Peng, McLellan, Jason S., Graham, Barney S., Xia, Ning-Shao
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5651723/
https://ncbi.nlm.nih.gov/pubmed/28539438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00176-17
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