A Vulnerable, Membrane-Proximal Site in Human Respiratory Syncytial Virus F Revealed by a Prefusion-Specific Single-Domain Antibody

Human respiratory syncytial virus (RSV) is a major cause of lower respiratory tract disease, especially in young children and the elderly. The fusion protein (F) exists in a pre- and postfusion conformation and is the main target of RSV-neutralizing antibodies. Highly potent RSV-neutralizing antibod...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Rossey, Iebe, Hsieh, Ching-Lin, Sedeyn, Koen, Ballegeer, Marlies, Schepens, Bert, McLellan, Jason S., Saelens, Xavier
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2021
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8139709/
https://ncbi.nlm.nih.gov/pubmed/33692208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02279-20
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