The AMP-Dependent Protein Kinase (AMPK) Activator A-769662 Causes Arterial Relaxation by Reducing Cytosolic Free Calcium Independently of an Increase in AMPK Phosphorylation

Although recent studies reveal that activation of the metabolic and Ca(2+) sensor AMPK strongly inhibits smooth muscle contraction, there is a paucity of information about the potential linkage between pharmacological AMPK activation and vascular smooth muscle (VSM) contraction regulation. Our aim w...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Huang, Yi, Smith, Corey A., Chen, Grace, Sharma, Bharti, Miner, Amy S., Barbee, Robert W., Ratz, Paul H.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5651270/
https://ncbi.nlm.nih.gov/pubmed/29093683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00756
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