Immune Repertoire after Immunization As Seen by Next-Generation Sequencing and Proteomics

The immune system produces a diverse repertoire of immunoglobulins in response to foreign antigens. During B-cell development, VDJ recombination and somatic mutations generate diversity, whereas selection processes remove it. Using both proteomic and NGS approaches, we characterized the immune reper...

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Bibliografiske detaljer
Udgivet i:Front Immunol
Main Authors: VanDuijn, Martijn M., Dekker, Lennard J., van IJcken, Wilfred F. J., Sillevis Smitt, Peter A. E., Luider, Theo M.
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2017
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5650670/
https://ncbi.nlm.nih.gov/pubmed/29085363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.01286
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