Ptpn11 Deletion in CD4(+) Cells Does Not Affect T Cell Development and Functions but Causes Cartilage Tumors in a T Cell-Independent Manner

The ubiquitously expressed tyrosine phosphatase Src homology region 2 domain-containing phosphatase-2 (SHP-2, encoded by Ptpn11) is required for constitutive cellular processes including proliferation, differentiation, and the regulation of immune responses. During development and maturation, subset...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Miah, S. M. Shahjahan, Jayasuriya, Chathuraka T., Salter, Alexander I., Reilly, Emma C., Fugere, Céline, Yang, Wentian, Chen, Qian, Brossay, Laurent
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5650614/
https://ncbi.nlm.nih.gov/pubmed/29085371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.01326
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