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Ligand modulation of sidechain dynamics in a wild-type human GPCR
GPCRs regulate all aspects of human physiology, and biophysical studies have deepened our understanding of GPCR conformational regulation by different ligands. Yet there is no experimental evidence for how sidechain dynamics control allosteric transitions between GPCR conformations. To address this...
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| Publicado no: | eLife |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
eLife Sciences Publications, Ltd
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5650471/ https://ncbi.nlm.nih.gov/pubmed/28984574 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.28505 |
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