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A Functional Selectivity Mechanism at the Serotonin-2A GPCR Involves Ligand-Dependent Conformations of Intracellular Loop 2

[Image: see text] With recent progress in determination of G protein-coupled receptor (GPCR) structure with crystallography, a variety of other experimental approaches (e.g., NMR spectroscopy, fluorescent-based assays, mass spectrometry techniques) are also being used to characterize state-specific...

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Publicat a:J Am Chem Soc
Autors principals: Perez-Aguilar, Jose Manuel, Shan, Jufang, LeVine, Michael V., Khelashvili, George, Weinstein, Harel
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2014
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4235374/
https://ncbi.nlm.nih.gov/pubmed/25314362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja508394x
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