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PROBING THE STRUCTURAL DETERMINANTS FOR THE FUNCTION OF INTRACELLULAR LOOP 2 IN STRUCTURALLY COGNATE G-PROTEIN COUPLED RECEPTORS
Intracellular loop 2 (IL2) in G-protein coupled receptors (GPCRs) is functionally important, e.g., in binding to G-protein and β-arrestin. Differences in secondary structure of IL2 in the crystal structures of the very similar β(1)- and β(2)-adrenergic receptors (β(1)AR, β(2)AR), i.e., an α-helix an...
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| Autors principals: | , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2010
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3005261/ https://ncbi.nlm.nih.gov/pubmed/21062002 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi100580s |
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