Structural determinants in the second intracellular loop of the human cannabinoid CB(1) receptor mediate selective coupling to G(s) and G(i)

BACKGROUND AND PURPOSE: The cannabinoid CB(1) receptor is primarily thought to be functionally coupled to the G(i) form of G proteins, through which it negatively regulates cAMP accumulation. Here, we investigated the dual coupling properties of CB(1) receptors and characterized the structural deter...

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Detalhes bibliográficos
Main Authors: Chen, XP, Yang, W, Fan, Y, Luo, JS, Hong, K, Wang, Z, Yan, JF, Chen, X, Lu, JX, Benovic, JL, Zhou, NM
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2010
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3010585/
https://ncbi.nlm.nih.gov/pubmed/20735408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2010.01006.x
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