Prolonged mitotic arrest induced by Wee1 inhibition sensitizes breast cancer cells to paclitaxel

Wee1 kinase is a crucial negative regulator of Cdk1/cyclin B1 activity and is required for normal entry into and exit from mitosis. Wee1 activity can be chemically inhibited by the small molecule MK-1775, which is currently being tested in phase I/II clinical trials in combination with other anti-ca...

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Vydáno v:Oncotarget
Hlavní autoři: Lewis, Cody W., Jin, Zhigang, Macdonald, Dawn, Wei, Wenya, Qian, Xu Jing, Choi, Won Shik, He, Ruicen, Sun, Xuejun, Chan, Gordon
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2017
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5650293/
https://ncbi.nlm.nih.gov/pubmed/29088738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.17848
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