Rapid Chagas disease drug target discovery using directed evolution in drug-sensitive yeast

Recent advances in cell-based, high-throughput phenotypic screening have identified new chemical compounds that are active against eukaryotic pathogens. A challenge to their future development lies in identifying these compounds’ molecular targets and binding modes. In particular, subsequent structu...

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Publicado no:ACS Chem Biol
Main Authors: Ottilie, Sabine, Goldgof, Gregory M., Calvet, Claudia Magalhaes, Jennings, Gareth K., LaMonte, Greg, Schenken, Jake, Vigil, Edgar, Kumar, Prianka, McCall, Laura-Isobel, Lopes, Eduardo Soares Constantino, Gunawan, Felicia, Yang, Jennifer, Suzuki, Yo, Siqueira-Neto, Jair L., McKerrow, James H., Amaro, Rommie E., Podust, Larissa M., Durrant, Jacob D., Winzeler, Elizabeth A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5649375/
https://ncbi.nlm.nih.gov/pubmed/27977118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.6b01037
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