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Motifs in the tau protein that control binding to microtubules and aggregation determine pathological effects
Tau pathology is associated with cognitive decline in Alzheimer’s disease, and missense tau mutations cause frontotemporal dementia. Hyperphosphorylation and misfolding of tau are considered critical steps leading to tauopathies. Here, we determine how motifs controlling conformational changes in th...
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| 發表在: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Nature Publishing Group UK
2017
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5648870/ https://ncbi.nlm.nih.gov/pubmed/29051562 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-13786-2 |
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