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Motifs in the tau protein that control binding to microtubules and aggregation determine pathological effects
Tau pathology is associated with cognitive decline in Alzheimer’s disease, and missense tau mutations cause frontotemporal dementia. Hyperphosphorylation and misfolding of tau are considered critical steps leading to tauopathies. Here, we determine how motifs controlling conformational changes in th...
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| Veröffentlicht in: | Sci Rep |
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| Hauptverfasser: | , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group UK
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5648870/ https://ncbi.nlm.nih.gov/pubmed/29051562 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-13786-2 |
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