Motifs in the tau protein that control binding to microtubules and aggregation determine pathological effects

Tau pathology is associated with cognitive decline in Alzheimer’s disease, and missense tau mutations cause frontotemporal dementia. Hyperphosphorylation and misfolding of tau are considered critical steps leading to tauopathies. Here, we determine how motifs controlling conformational changes in th...

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Udgivet i:Sci Rep
Main Authors: Lathuilière, Aurélien, Valdés, Pamela, Papin, Stéphanie, Cacquevel, Matthias, Maclachlan, Catherine, Knott, Graham W., Muhs, Andreas, Paganetti, Paolo, Schneider, Bernard L.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5648870/
https://ncbi.nlm.nih.gov/pubmed/29051562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-13786-2
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