Motifs in the tau protein that control binding to microtubules and aggregation determine pathological effects

Tau pathology is associated with cognitive decline in Alzheimer’s disease, and missense tau mutations cause frontotemporal dementia. Hyperphosphorylation and misfolding of tau are considered critical steps leading to tauopathies. Here, we determine how motifs controlling conformational changes in th...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Lathuilière, Aurélien, Valdés, Pamela, Papin, Stéphanie, Cacquevel, Matthias, Maclachlan, Catherine, Knott, Graham W., Muhs, Andreas, Paganetti, Paolo, Schneider, Bernard L.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2017
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5648870/
https://ncbi.nlm.nih.gov/pubmed/29051562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-13786-2
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg