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The giant protein titin regulates the length of the striated muscle thick filament

The contractile machinery of heart and skeletal muscles has as an essential component the thick filament, comprised of the molecular motor myosin. The thick filament is of a precisely controlled length, defining thereby the force level that muscles generate and how this force varies with muscle leng...

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Publicat a:Nat Commun
Autors principals: Tonino, Paola, Kiss, Balazs, Strom, Josh, Methawasin, Mei, Smith, John E., Kolb, Justin, Labeit, Siegfried, Granzier, Henk
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2017
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5648799/
https://ncbi.nlm.nih.gov/pubmed/29051486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01144-9
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