A novel small molecule inhibitor of p32 mitochondrial protein overexpressed in glioma

BACKGROUND: The mitochondrial protein p32 is a validated therapeutic target of cancer overexpressed in glioma. Therapeutic targeting of p32 with monoclonal antibody or p32-binding LyP-1 tumor-homing peptide can limit tumor growth. However, these agents do not specifically target mitochondrial-locali...

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Bibliografiske detaljer
Udgivet i:J Transl Med
Main Authors: Yenugonda, Venkata, Nomura, Natsuko, Kouznetsova, Valentina, Tsigelny, Igor, Fogal, Valentina, Nurmemmedov, Elmar, Kesari, Santosh, Babic, Ivan
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2017
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5648515/
https://ncbi.nlm.nih.gov/pubmed/29047383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-017-1312-7
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