Multiple spatially related pharmacophores define small molecule inhibitors of OLIG2 in glioblastoma

Transcription factors (TFs) are a major class of protein signaling molecules that play key cellular roles in cancers such as the highly lethal brain cancer—glioblastoma (GBM). However, the development of specific TF inhibitors has proved difficult owing to expansive protein-protein interfaces and th...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Tsigelny, Igor F., Mukthavaram, Rajesh, Kouznetsova, Valentina L., Chao, Ying, Babic, Ivan, Nurmemmedov, Elmar, Pastorino, Sandra, Jiang, Pengfei, Calligaris, David, Agar, Nathalie, Scadeng, Miriam, Pingle, Sandeep C., Wrasidlo, Wolfgang, Makale, Milan T., Kesari, Santosh
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2015
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5410230/
https://ncbi.nlm.nih.gov/pubmed/26517684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.5633
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