Multiple spatially related pharmacophores define small molecule inhibitors of OLIG2 in glioblastoma

Transcription factors (TFs) are a major class of protein signaling molecules that play key cellular roles in cancers such as the highly lethal brain cancer—glioblastoma (GBM). However, the development of specific TF inhibitors has proved difficult owing to expansive protein-protein interfaces and th...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Tsigelny, Igor F., Mukthavaram, Rajesh, Kouznetsova, Valentina L., Chao, Ying, Babic, Ivan, Nurmemmedov, Elmar, Pastorino, Sandra, Jiang, Pengfei, Calligaris, David, Agar, Nathalie, Scadeng, Miriam, Pingle, Sandeep C., Wrasidlo, Wolfgang, Makale, Milan T., Kesari, Santosh
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5410230/
https://ncbi.nlm.nih.gov/pubmed/26517684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.5633
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