Multiple spatially related pharmacophores define small molecule inhibitors of OLIG2 in glioblastoma

Transcription factors (TFs) are a major class of protein signaling molecules that play key cellular roles in cancers such as the highly lethal brain cancer—glioblastoma (GBM). However, the development of specific TF inhibitors has proved difficult owing to expansive protein-protein interfaces and th...

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Publicado en:Oncotarget
Autores principales: Tsigelny, Igor F., Mukthavaram, Rajesh, Kouznetsova, Valentina L., Chao, Ying, Babic, Ivan, Nurmemmedov, Elmar, Pastorino, Sandra, Jiang, Pengfei, Calligaris, David, Agar, Nathalie, Scadeng, Miriam, Pingle, Sandeep C., Wrasidlo, Wolfgang, Makale, Milan T., Kesari, Santosh
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5410230/
https://ncbi.nlm.nih.gov/pubmed/26517684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.5633
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