Effect of the JAK2/STAT3 inhibitor SAR317461 on human glioblastoma tumorspheres

BACKGROUND: The STAT3 transcription factor is a major intracellular signaling protein and is frequently dysregulated in the most common and lethal brain malignancy in adults, glioblastoma multiforme (GBM). Activation of STAT3 in GBM correlates with malignancy and poor prognosis. The phosphorylating...

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Detalhes bibliográficos
Publicado no:J Transl Med
Main Authors: Mukthavaram, Rajesh, Ouyang, Xiao, Saklecha, Rohit, Jiang, Pengfei, Nomura, Natsuko, Pingle, Sandeep C, Guo, Fang, Makale, Milan, Kesari, Santosh
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4539675/
https://ncbi.nlm.nih.gov/pubmed/26283544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-015-0627-5
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