High-efficiency liposomal encapsulation of a tyrosine kinase inhibitor leads to improved in vivo toxicity and tumor response profile

Staurosporine (STS) is a potent pan-kinase inhibitor with marked activity against several chemotherapy-resistant tumor types in vitro. The translational progress of this compound has been hindered by poor pharmacokinetics and toxicity. We sought to determine whether liposomal encapsulation of STS wo...

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Библиографические подробности
Главные авторы: Mukthavaram, Rajesh, Jiang, Pengfei, Saklecha, Rohit, Simberg, Dmitri, Bharati, Ila Sri, Nomura, Natsuko, Chao, Ying, Pastorino, Sandra, Pingle, Sandeep C, Fogal, Valentina, Wrasidlo, Wolf, Makale, Milan, Kesari, Santosh
Формат: Artigo
Язык:Inglês
Опубликовано: Dove Medical Press 2013
Предметы:
Original Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3808212/
https://ncbi.nlm.nih.gov/pubmed/24174874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S51949
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