High-efficiency liposomal encapsulation of a tyrosine kinase inhibitor leads to improved in vivo toxicity and tumor response profile

Staurosporine (STS) is a potent pan-kinase inhibitor with marked activity against several chemotherapy-resistant tumor types in vitro. The translational progress of this compound has been hindered by poor pharmacokinetics and toxicity. We sought to determine whether liposomal encapsulation of STS wo...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Mukthavaram, Rajesh, Jiang, Pengfei, Saklecha, Rohit, Simberg, Dmitri, Bharati, Ila Sri, Nomura, Natsuko, Chao, Ying, Pastorino, Sandra, Pingle, Sandeep C, Fogal, Valentina, Wrasidlo, Wolf, Makale, Milan, Kesari, Santosh
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Dove Medical Press 2013
Θέματα:
Original Research
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3808212/
https://ncbi.nlm.nih.gov/pubmed/24174874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S51949
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