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Protein Displacement by Herpes Helicase-Primase and the Key Role of UL42 During Helicase-Coupled DNA Synthesis by the Herpes Polymerase

The herpes helicase-primase (UL5-UL8-UL52) very inefficiently unwinds double stranded DNA. To better understand the mechanistic consequences of this inefficiency, we investigated protein displacement activity by UL5-UL8-UL52, as well as the impact of coupling DNA synthesis by the herpes polymerase w...

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Publicat a:Biochemistry
Autors principals: Dickerson, Sarah Michelle, Kuchta, Robert D.
Format: Artigo
Idioma:Inglês
Publicat: 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5648053/
https://ncbi.nlm.nih.gov/pubmed/28505413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b01128
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