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The regulatory isoform rPGRP-LC resolves immune activation through ESCRT-mediated receptor clearance

The innate immune system needs to distinguish between harmful and innocuous stimuli to adapt immune activation to the level of threat. How Drosophila mounts differential immune responses to dead and live Gram-negative bacteria using the single peptidoglycan receptor PGRP-LC is unknown. We describe a...

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Détails bibliographiques
Publié dans:Nat Immunol
Auteurs principaux: Neyen, Claudine, Runchel, Christopher, Schüpfer, Fanny, Meier, Pascal, Lemaitre, Bruno
Format: Artigo
Langue:Inglês
Publié: 2016
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5648041/
https://ncbi.nlm.nih.gov/pubmed/27548432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3536
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