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The regulatory isoform rPGRP-LC resolves immune activation through ESCRT-mediated receptor clearance

The innate immune system needs to distinguish between harmful and innocuous stimuli to adapt immune activation to the level of threat. How Drosophila mounts differential immune responses to dead and live Gram-negative bacteria using the single peptidoglycan receptor PGRP-LC is unknown. We describe a...

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Detalhes bibliográficos
Publicado no:Nat Immunol
Main Authors: Neyen, Claudine, Runchel, Christopher, Schüpfer, Fanny, Meier, Pascal, Lemaitre, Bruno
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5648041/
https://ncbi.nlm.nih.gov/pubmed/27548432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3536
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