Nitric oxide donor [Ru(terpy)(bdq)NO](3+) induces uncoupling and phosphorylation of endothelial nitric oxide synthase promoting oxidant production

[Ru(terpy)(bdq)NO](3+) (TERPY) is a nitric oxide (NO) donor that promotes relaxation of the mesenteric artery and aorta in rats. We sought to investigate whether it acts as both an NO donor and endothelial NO synthase (eNOS) activator, as shown previously for nitroglycerin. Human umbilical vein endo...

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Veröffentlicht in:Free Radic Biol Med
Hauptverfasser: Potje, Simone R., Chen, Zhenlong, Oliveira, Suellen D’Arc S., Bendhack, Lusiane M., da Silva, Roberto S., Bonini, Marcelo G., Antoniali, Cristina, Minshall, Richard D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5647835/
https://ncbi.nlm.nih.gov/pubmed/28899725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2017.09.004
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