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I-BET151 inhibits expression of RANKL, OPG, MMP3 and MMP9 in ankylosing spondylitis in vivo and in vitro

Ankylosing spondylitis (AS) is characterized by osteoclastogenesis and inflammatory bone resorption. The present study aimed to investigate the effect of bromodomain and extra-terminal domain (BET) protein inhibitor I-BET151 on AS process. A total of 38 AS Chinese patients were recruited and a furth...

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Bibliographische Detailangaben
Veröffentlicht in:Exp Ther Med
Hauptverfasser: Fan, Jianping, Zhao, Jian, Shao, Jie, Wei, Xianzhao, Zhu, Xiaodong, Li, Ming
Format: Artigo
Sprache:Inglês
Veröffentlicht: D.A. Spandidos 2017
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5647692/
https://ncbi.nlm.nih.gov/pubmed/29067128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/etm.2017.5032
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