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Molecular Simulations Suggest a Force-Dependent Mechanism of Vinculin Activation

Focal adhesions are dynamic constructs at the leading edge of migrating cells, linking them to the extracellular matrix and enabling force sensing and transmission. The lifecycle of a focal adhesion is a highly coordinated process involving spatial and temporal variations of protein composition, int...

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Detalles Bibliográficos
Publicado en:Biophys J
Main Authors: Sun, Li, Noel, Jeffrey K., Levine, Herbert, Onuchic, José N.
Formato: Artigo
Idioma:Inglês
Publicado: The Biophysical Society 2017
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5647571/
https://ncbi.nlm.nih.gov/pubmed/29045864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2017.08.037
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