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Binding of protofibrillar Aβ trimers to lipid bilayer surface enhances Aβ structural stability and causes membrane thinning
Alzheimer’s disease (AD), a common neurodegenerative disease, is characterized by the aggregation of amyloid-β (Aβ) peptides. The interactions of Aβ with membranes cause changes in membrane morphology and ion permeation, which are responsible for its neurotoxicity and can accelerate fibril growth. H...
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| Veröffentlicht in: | Phys Chem Chem Phys |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5647258/ https://ncbi.nlm.nih.gov/pubmed/28979963 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7cp05959k |
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