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Binding of protofibrillar Aβ trimers to lipid bilayer surface enhances Aβ structural stability and causes membrane thinning

Alzheimer’s disease (AD), a common neurodegenerative disease, is characterized by the aggregation of amyloid-β (Aβ) peptides. The interactions of Aβ with membranes cause changes in membrane morphology and ion permeation, which are responsible for its neurotoxicity and can accelerate fibril growth. H...

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Detalhes bibliográficos
Publicado no:Phys Chem Chem Phys
Main Authors: Dong, Xuewei, Sun, Yunxiang, Wei, Guanghong, Nussinov, Ruth, Ma, Buyong
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5647258/
https://ncbi.nlm.nih.gov/pubmed/28979963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7cp05959k
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