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Intracellular uncaging of cGMP with blue light

We have made a new caged cGMP that is photolyzed with blue light. Using our recently developed derivative of 7-diethylaminocourmarin (DEAC) called DEAC450, we synthesized coumarin phosphoester derivatives of cGMP with two negative charges appended to the DEAC450 moiety. DEAC450-cGMP is freely solubl...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:ACS Chem Neurosci
Prif Awduron: Agarwal, Hitesh K., Zhai, Shenyu, Surmeier, D. James, Ellis-Davies, Graham C. R.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2017
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5647252/
https://ncbi.nlm.nih.gov/pubmed/28762726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.7b00237
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