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Integrating cardiomyocytes from human pluripotent stem cells in safety pharmacology: has the time come?
Cardiotoxicity is a severe side effect of drugs that induce structural or electrophysiological changes in heart muscle cells. As a result, the heart undergoes failure and potentially lethal arrhythmias. It is still a major reason for drug failure in preclinical and clinical phases of drug discovery....
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| Publicado en: | Br J Pharmacol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
John Wiley and Sons Inc.
2016
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5647193/ https://ncbi.nlm.nih.gov/pubmed/27641943 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13577 |
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