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Pyruvate Kinase M2 Is Required for the Expression of the Immune Checkpoint PD-L1 in Immune Cells and Tumors
Blocking interaction of the immune checkpoint receptor PD-1 with its ligand PD-L1 is associated with good clinical outcomes in a broad variety of malignancies. High levels of PD-L1 promote tumor growth by restraining CD8(+) T-cell responses against tumors. Limiting PD-L1 expression and function is t...
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| Yayımlandı: | Front Immunol |
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| Asıl Yazarlar: | , , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Frontiers Media S.A.
2017
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5646285/ https://ncbi.nlm.nih.gov/pubmed/29081778 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.01300 |
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