Pyruvate Kinase M2 Is Required for the Expression of the Immune Checkpoint PD-L1 in Immune Cells and Tumors

Blocking interaction of the immune checkpoint receptor PD-1 with its ligand PD-L1 is associated with good clinical outcomes in a broad variety of malignancies. High levels of PD-L1 promote tumor growth by restraining CD8(+) T-cell responses against tumors. Limiting PD-L1 expression and function is t...

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Udgivet i:Front Immunol
Main Authors: Palsson-McDermott, Eva M., Dyck, Lydia, Zasłona, Zbigniew, Menon, Deepthi, McGettrick, Anne F., Mills, Kingston H. G., O’Neill, Luke A.
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2017
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5646285/
https://ncbi.nlm.nih.gov/pubmed/29081778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.01300
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