USP11 regulates PML stability to control Notch-induced malignancy in brain tumours

The promyelocytic leukaemia (PML) protein controls multiple tumour suppressive functions and is downregulated in diverse types of human cancers through incompletely characterized post-translational mechanisms. Here we identify USP11 as a PML regulator by RNAi screening. USP11 deubiquitinates and sta...

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Pubblicato in:Nat Commun
Autori principali: Wu, Hsin-Chieh, Lin, Yu-Ching, Liu, Cheng-Hsin, Chung, Hsiang-Ching, Wang, Ya-Ting, Lin, Ya-Wen, Ma, Hsin-I., Tu, Pang-Hsien, Lawler, Sean E., Chen, Ruey-Hwa
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5645609/
https://ncbi.nlm.nih.gov/pubmed/24487962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms4214
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