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MOLECULAR ANALYSIS: MICROSATELLITY INSTABILITY AND LOSS OF HETEROZYGOSITY OF TUMOR SUPPRESSOR GENE IN HEREDITARY NON-POLYPOSIS COLORECTAL CANCERS (HNPCC)
HNPCC (Hereditary non-polyposis colorectal cancers) development is caused by mutation of genes included in system of mismatch repair genes. The mutation exists at 60% of patients in hMSH2 gene, 30% in hMLH1 and 10% both in hPMS1and hPMS2 genes. RER+ exists in about 90% in hereditary non-polyposis co...
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| 發表在: | Bosn J Basic Med Sci |
|---|---|
| Main Authors: | , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina
2009
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5645541/ https://ncbi.nlm.nih.gov/pubmed/19284389 |
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