HIV-1 viral protein R (Vpr) induces fatty liver in mice via LXRα and PPARα dysregulation: implications for HIV-specific pathogenesis of NAFLD

HIV patients develop hepatic steatosis. We investigated hepatic steatosis in transgenic mice expressing the HIV-1 accessory protein Vpr (Vpr-Tg) in liver and adipose tissues, and WT mice infused with synthetic Vpr. Vpr-Tg mice developed increased liver triglyceride content and elevated ALT, bilirubi...

全面介紹

Na minha lista:
書目詳細資料
發表在:Sci Rep
Main Authors: Agarwal, Neeti, Iyer, Dinakar, Gabbi, Chiara, Saha, Pradip, Patel, Sanjeet G., Mo, Qianxing, Chang, Benny, Goswami, Biman, Schubert, Ulrich, Kopp, Jeffrey B., Lewis, Dorothy E., Balasubramanyam, Ashok
格式: Artigo
語言:Inglês
出版: Nature Publishing Group UK 2017
主題:
Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5645472/
https://ncbi.nlm.nih.gov/pubmed/29042644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-13835-w
標簽: 添加標簽
沒有標簽, 成為第一個標記此記錄!

相似書籍